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. Author manuscript; available in PMC: 2018 Jul 3.
Published in final edited form as: Cell Rep. 2018 May 8;23(6):1840–1852. doi: 10.1016/j.celrep.2018.04.012

Figure 5. Mutational Analysis of Type II Cadherin Specificity Using SPR.

Figure 5

(A) SPR responses of wild-type or specificity mutants of cadherin-6 and cadherin-11 (columns) passed over wild-type cadherin-6, cadherin-9, cadherin-10, cadherin-8, and cadherin-11 surfaces (rows).

(B) Chimeric proteins cad-6EC111EC2 and cad-11EC16EC2 passed over the same surfaces reproduce the binding characteristics of the wild-type proteins with corresponding EC1 domains.

All mutant and chimeric proteins retained homophilic binding in AUC (Table 1).