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. Author manuscript; available in PMC: 2018 Jul 3.
Published in final edited form as: Cell Rep. 2018 May 8;23(6):1840–1852. doi: 10.1016/j.celrep.2018.04.012

Figure 6. Full-Length Type II Cadherin Localization at Homotypic and Heterotypic Contact Sites between Transfected A431D Cells in Co-culture.

Figure 6

Fluorescence images of co-cultures of A431D cells transfected with full-length type II cadherins tagged with either cherry (red) or dendra (green) in the combinations indicated.

(A–E) Wild-type cadherin-11/-11 (A), cadherin-8/-11 (B), cadherin-6/-11 (C), cadherin-8/-10 (D) and cadherin-6/-10 (E) localize to homotypic and heterotypic contact sites according to their binding preferences.

(F–J) Mutations targeting specificity determinants alter localization of mutant cadherin-11 with cadherin-11 (F), cadherin-8 (G) and cadherin-6 (H) and of mutant cadherin-6 with cadherins-11 (I) and cadherin-10 (J). Compare panels linked with arrows. Heterotypic contact sites are delimited by arrowheads at top and bottom.

Scale bar, 50 μm. See also Figure S2.