Skip to main content
. Author manuscript; available in PMC: 2018 Aug 28.
Published in final edited form as: Chem Rev. 2018 Jan 31;118(4):1917–1950. doi: 10.1021/acs.chemrev.7b00534

Figure 21. Ion-exchange nanodetector.

Figure 21

(a) Schematic of surface acoustic wave (SAW) device and SAW-induced lysing of exosomes to release RNA for detection. SAWs generated at the transducer refract into the liquid bulk, inducing fluid motion, and electromechanical coupling also generates a complimentary electric wave at the surface of the substrate. (b) Schematic of ion-exchange nano-membrane sensor consisting of two reservoirs separated by the membrane. RNA in the sensing reservoir hybridize to complimentary oligos immobilized on the surface of the membrane. The inset shows the ion transport through the device to generate current. (c) Representative current voltage characteristic (CVC) for nano-membrane sensor. The black, red, and blue curves indicate a CVC taken with the bare membrane, a CVC taken with the probe attached to the membrane, and a CVC taken with the probes on the membrane surface fully saturated with target RNA, respectively. (d) Target RNA concentration as detected by the nano-membrane sensor and determined using the universal calibration curve before and after SAW lysis for two different nano-membrane devices. Reprinted with permission from Ref 188. Copyright 2015 The Royal Society of Chemistry.