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. Author manuscript; available in PMC: 2018 Aug 28.
Published in final edited form as: Chem Rev. 2018 Jan 31;118(4):1917–1950. doi: 10.1021/acs.chemrev.7b00534

Figure 22. Localized surface plasmonic resonance for detecting EV RNA.

Figure 22

(a) Scanning electron microscopy (SEM) image of gold nanoprisms for LSPR-based sensors fabrication. (b) Assay schematic of the LSPR assay. The immobilized nanoprisms are functionalized with capturing DNA probes and polyethylene glycol spacers. Upon hybridization of the miRNA target (miR-10b) with the capturing DNA probes, the LSPR resonant peak shifts. (c) miR-10b detection in clinical samples from pancreatic ductal adenocarcinoma (PDAC; left) or chronic pancreatitis (CP; right) patients. Determination of the miRNA levels was performed in plasma, exosomes and supernatants, respectively. Reprinted with permission from Ref 192. Copyright 2015 American Chemical Society.