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. Author manuscript; available in PMC: 2018 Aug 28.
Published in final edited form as: Chem Rev. 2018 Jan 31;118(4):1917–1950. doi: 10.1021/acs.chemrev.7b00534

Figure 27. Breast cancer detection.

Figure 27

(a, b) qPCR analysis of miRNA in exosomes derived from mammary epithelial cells (MCF10A) and breast cancer cell lines (MCF7, ZR-75-1, T47D, MDA-MB-231, BT-20, BT-474, SK-BR-3). Fold change in expression is shown for the exosome miRNA relative to their cellular miRNA levels and normalized against spike-in miRNA control. (c, d) qPCR analysis of exosome miRNA expression in normal plasma and plasma from breast cancer patients (n =16). Exosomes were isolated from the plasma samples using commercial reagents and total RNA was extracted for qPCR analysis. Reprinted with permission from Ref 266. Copyright 2016 Hannafon et al.