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. Author manuscript; available in PMC: 2018 Aug 28.
Published in final edited form as: Chem Rev. 2018 Jan 31;118(4):1917–1950. doi: 10.1021/acs.chemrev.7b00534

Figure 29. Detection of acute kidney injury.

Figure 29

(a) Fetuin-A, a novel kidney injury marker, could be found inside rat urinary vesicles after cisplatin-induced acute kidney injury (AKI). Inset shows a magnified image of a urinary vesicle labeled with gold-conjugated anti-Fetuin-A. (b) Temporal secretion of urinary exosomal Fetuin-A in different AKI animal models. Western blotting analysis of urinary vesicles obtained from three rat models: one rat pre-, day 0, day 1, and day 2 after cisplatin injection; one rat from pre- and 8 h after bilateral ischemia and reperfusion (I/R); one rat from pre- and 24–30 h after volume depletion (VD). (c) Level of Fetuin-A in urinary vesicles of intensive care unit (ICU) patients with and without AKI, as compared to healthy volunteers. Reprinted with permission from Ref 241. Copyright 2006 International Society of Nephrology.