Table 4.

Different types of RNA found in EVs.

RNA	Functions	Coding	Typical Size
Messenger RNA (mRNA)	Protein translation	Yes	400 – 12,000 nt average ~ 2,100 nt
MicroRNA (miRNA)	Post-transcriptional gene silencing	No	17 – 24 nt
Y RNA	Component of Ro60 ribonucleoprotein particle; initiation factor for DNA replication	No	~ 100 nt
Signal Recognition Particle RNA (SRP RNA)	Component of SRP ribonucleoprotein complex that directs protein trafficking	No	~ 280 nt
Transfer RNA (tRNA)	Adapter for matching amino acid to mRNA	No	76 – 90 nt
Ribosomal RNA (rRNA)	RNA component of ribosome	No	18S (1.9 kb) 28S (5.0 kb)
Small nuclear RNA (snRNA)	RNA processing such as mRNA splicing	No	~ 150 nt
Small nucleolar RNA (snoRNA)	Guiding chemical modifications of other RNAs	No	20 – 24 nt
Long noncoding RNA (lncRNA)	Many putative functions, including in-transcription and post-transcription regulations	No	> 100 nt

nt: nucleotides, kb: kilobases