Fig. 7.

The FGF19-Src-FXR axis is likely defective in PBC patients. a Hepatic mRNA levels of the indicated genes in PBC patients were measured by qRT-PCR (n = 15). b Liver sections from normal and PBC patients were performed by IHC using the p-Y67-FXR, FXR, p-Y416-Src, and Src antibodies. Scale bar, 50 µm. c Hepatic levels of indicated proteins in randomly selected 7 normal subjects and PBC patients were measured by IB. d Expression levels of the indicated proteins are shown with the normal values set to 1. All values are presented as mean ± SD. a, d Statistical significance was measured using the Student t-test. **P < 0.01