Table 3.
Univariate and multivariate analysis of the correlation between OS and the analyzed independent variables.
| Variable | Univariate | Multivariate | ||
|---|---|---|---|---|
| Median OS (95% CI) | p-value | Hazard Ratio OS (95% CI) | p-value | |
| Gender | ||||
| Male | 9.1 (6.1–12.1) | 0.100 | ||
| Female | 5.1 (3.9–6.3) | |||
| Etiology | ||||
| Viral | 6.1 (4.9–7.3) | 0.309 | ||
| Non-Viral | 5.1 (3.8–6.4) | |||
| Era of enrollment | ||||
| 2006–2011 (0) | 6.1 (4.1–8.1) | 0.960 | ||
| 2012–2017 (1) | 5.0 (2.2–7.8) | |||
| Child-Pugh | ||||
| B7 | 6.1 (4.7–7.5) | 0.816 | ||
| B8-B9 | 5.1 (3.3–6.9) | |||
| BCLC | ||||
| B | 7.8 (6.3–9.3) | 0.092 | *Excluded for co-linearity with macrovascular invasion and extra-hepatic spread | |
| C | 5.0 (3.6–6.4) | |||
| ECOG-PS | ||||
| 0 | 6.1 (4.8–7.5) | 0.533 | ||
| 1–2 | 5.4 (4.0–6.8) | |||
| Macrovascular invasion | ||||
| Absent | 7.1 (5.5–8.7) | 0.042 | 1.336 (0.876–2.040) | 0.179 |
| Present | 5.0 (3.8–6.2) | |||
| Extra-hepatic spread | ||||
| Absent | 7.0 (5.9–8.1) | 0.058 | 1.950 (1.135–3.350) | 0.016 |
| Present | 3.1 (2.9–3.3) | |||
| AFP (ng/mL) | ||||
| <400 | 6.1 (4.5–7.7) | 0.151 | ||
| >400 | 5.4 (3.0–7.8) | |||
| Treatment group | ||||
| MC | 7.5 (3.7–11–3) | 0.013 | 0.525 (0.332–0.829) | 0.006 |
| BSC | 5.1 (4.1–6.1) | |||
BCLC = Barcellona Clinic Liver Cancer; ECOG-PS = Eastern Cooperative Oncology Group-Performance Status; AFP = Alpha-fetoprotein; MC = Metronomic capecitabine; BSC = Best supportive care.