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. 2018 Jul 3;8:9993. doi: 10.1038/s41598-018-28404-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Recovery of TsCIA following in vivo treatment with NBI74330. (a) Time schedule for NBI74330 treatment in TsCIA. (b) Clinical scores of TsCIA treated with CXCR3-specific antagonist NBI74330 in (a) (n = 4 tree shrews per group, *p < 0.05). AU indicates arbitrary unit. (c) Average body weights. (d–g) H&E images of lung tissues in vehicle- or NBI74330-treated TsCIA at day 21. Infiltrated PBMCs are indicated by arrows. Scale bar: 200 μm (d and e) and 100 μm (f and g). (h) Infiltrated cell area was compared between TsCIA and TsCIA-NBI74330 by NIH ImageJ software (**p < 0.01. Error bars indicate SEM). (i) Quantification of mRNA levels of the inflammatory factors in TsCIA lungs and TsCIA-NBI74330 lungs (n = 4 tree shrews per group, *p < 0.05, **p < 0.01. Error bars indicate SEM).