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. 2018 Jul 3;9(7):741. doi: 10.1038/s41419-018-0782-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — In cervical cancer, several Wnt/β-catenin signaling antagonists including SOX17 revealed low expression because of hypermethylation. SOX17 could recognize and bind to the β-catenin promoter region as a transcription repressor and reduce the accumulation of nuclear β-catenin, leading to the down-regulation of target genes, such as cyclin D1 and c-myc. Consequently, the activity of Wnt/β-catenin signaling pathway was attenuated, resulting in cancer cell proliferation and tumor formation inhibition in cervical cancer cells