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. 2018 Jul 3;9:2587. doi: 10.1038/s41467-018-04983-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Biosynthesis of novofumigatonin. a Proposed biosynthetic pathway of novofumigatonin (1). Boxed compounds were isolated in this study. Detailed procedures for isolation and structural determination of the metabolites are provided in the Supplementary Notes 1 to 18. b LC–MS analysis of metabolites from gene-deletion mutants. Extracted ion chromatograms (EICs) at m/z 423.251 (for 4), 431.243 (for 5), 431.279 (for 11), 445.259 (for 12), 447.275 (for 2), 457.256 (for 6), 461.217 (for 1), 465.248 (for 15 and 18), 477.212 (for 19), and 495.259 (for 14), are shown. c LC–MS analysis after the deletion of e-anaPS. Base peak chromatograms are shown. d HPLC analysis of the metabolites from A. oryzae transformants. Chromatograms were monitored at 300 nm. e, f LC–MS analyses of the metabolites from A. oryzae transformants. The structures of compounds 21 and 22 are shown in Fig. 4