Table 2.
Cortical regions | Max | VtxMax | Size (mm2) | TalXb | TalYb | TalZb | CWP |
---|---|---|---|---|---|---|---|
Thinner in MDD patientsa | |||||||
Left hemisphere | |||||||
inferior parietal and lateral occipital cortices | 4.051 | 27613 | 2026.93 | −40.1 | −62.0 | 6.6 | 0.0004 |
superior frontal, medial orbitofrontal cortices | 2.640 | 152852 | 1948.08 | −8.2 | 2.2 | 50.3 | 0.0013 |
caudal middle frontal cortices | 3.084 | 105971 | 1511.15 | −27.5 | 5.8 | 46.4 | 0.0095 |
Right hemisphere | |||||||
superior frontal and medial orbitofrontal cortices | 3.002 | 92871 | 1978.74 | 8.0 | 19.7 | 41.2 | 0.0012 |
precentral cortex | 3.376 | 140561 | 1929.42 | 50.4 | 1.2 | 36.7 | 0.0013 |
inferior parietal and supra-marginal cortices | 3.814 | 33905 | 1868.01 | 52.9 | −45.0 | 27.2 | 0.0015 |
lateral occipital cortex | 4.195 | 158509 | 1508.89 | 47.1 | −68.8 | 12.4 | 0.0089 |
Correlation with serum IL-6 level in MDD patientsa | |||||||
Left hemisphere | |||||||
triangularis | −4.309 | 16892 | 8536.62 | −29.5 | 22.1 | 9.3 | 0.0001 |
superior frontal, medial orbitofrontal, and paracentral cortices | −3.701 | 64159 | 3064.38 | −13.5 | 44.6 | 1.0 | 0.0001 |
parahippocampal cortex | −4.928 | 70540 | 2386.87 | −28.1 | −30.6 | −14.5 | 0.0001 |
rostral middle frontal cortex | −2.691 | 149979 | 1498.34 | −22.1 | 38.7 | 19.7 | 0.0168 |
middle temporal cortex | −4.576 | 24712 | 1421.53 | −47.2 | −33.3 | −4.9 | 0.0218 |
Right hemisphere | |||||||
caudal middle frontal cortex, insula, and opercularis | −4.132 | 23947 | 5844.73 | 31.1 | 17.1 | 9.8 | 0.0001 |
superior and middle temporal cortices | −4.777 | 163449 | 5260.70 | 47.2 | −21.7 | −10.2 | 0.0001 |
superior frontal, medial orbitofrontal, and cingulate cortices | −4.888 | 12712 | 3690.45 | 13.6 | −40.6 | 32.6 | 0.0001 |
parahippocampal cortex | −4.470 | 9976 | 2465.30 | 32.1 | −29.5 | −13.9 | 0.0001 |
MDD, major depressive disorder; CWP = opercularis clusterwise p value.
aSignificantly thinner cortical regions and IL-6-associated regions in MDD patients were detected using FreeSurfer v 6.0. p < 0.05 (Monte-Carlo simulation).
bBased on Talairach and Toumoux system.