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. 2018 Jul 3;8:10050. doi: 10.1038/s41598-018-28280-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) The volcano plot. Orange represents DEGs; the downregulated DEGs are on the left side of the midline, and the upregulated DEGs are on the right. OA represents osteoarthritis patients; HC represents healthy controls. (B) The dendrogram. Profiles of DEGs in synovitis of OA. Data of mRNA were clustered using GCBI (P < 0.05). In total, 1941 DEGs were determined compared to the HC group (yellow). The OA group is blue, and the HC group is yellow.