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. 2018 Jul 3;8:10050. doi: 10.1038/s41598-018-28280-6

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© The Author(s) 2018

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The dots represent genes, and the size represents the degree value (the greater the value is, the more important the pathway is). Red represents upregulation and blue represents downregulation. Arrows represent the relationship between upstream and downstream. The dotted line indicates the indirect action.