Table 4.
The top 15 betweenness centrality values of the gene signal network analysis. Greater betweenness values indicate genes with greater importance.
| Gene symbol | Gene feature | Gene Description | Betweenness |
|---|---|---|---|
| NRAS | up | neuroblastoma RAS viral (v-ras) oncogene homolog | 2509.5 |
| SPHK2 | up | sphingosine kinase 2 | 2509 |
| FOS | up | FBJ murine osteosarcoma viral oncogene homolog | 2478.83 |
| CXCR4 | up | chemokine (C-X-C motif) receptor 4 | 2313.33 |
| PLD1 | up | phospholipase D1, phosphatidylcholine-specific | 2168.5 |
| GNAI2 | up | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | 1767.17 |
| PLA2G4F | down | phospholipase A2, group IVF | 1693 |
| PIK3R2 | up | phosphoinositide-3-kinase, regulatory subunit 2 (beta) | 1375 |
| PRKCA | up | protein kinase C, alpha | 1328 |
| ASAH1 | up | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | 1260 |
| CCL5 | up | chemokine (C-C motif) ligand 5 | 1116.67 |
| CCL3 | up | chemokine (C-C motif) ligand 3 | 1057.67 |
| UGCG | up | UDP-glucose ceramide glucosyltransferase | 1008 |
| RELA | up | v-rel avian reticuloendotheliosis viral oncogene homologue A | 999 |
| ITGB5 | up | integrin, beta 5 | 969 |