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. 2018 Jul 3;9(7):740. doi: 10.1038/s41419-018-0756-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Schematic of Drosophila core cell death machinery. b–g Merged Z-stack confocal images of the abdominal muscles stained with phalloidin (green) at 12 h APF. DEOM1 is outlined with a solid yellow line and histolysed DEOM1s are marked by yellow asterisks. b Histolysis proceeds normally in mef2-Gal4/+ muscles. Overexpression of DIAPI (c) or p35 (d) in muscles partially blocks DEOM1 histolysis. e–g There is no significant difference in DEOM1 histolysis upon RNAi knockdown of tn alone (e), or with overexpression of DIAP1 (f) or p35 (g) in a tn RNAi background. h A bar graph showing similar levels of muscle histolysis in mef2>tn RNAi+DIAP1 OE compared to mef2>tn RNAi muscles. i Quantification showing no significant difference in DEOM1 breakdown between mef2>tn RNAi and mef2>tn RNAi+p35 OE pupae. Mean ± SEM (n.s., not significant, ****p < 0.001, ***p < 0.005, **p < 0.01). Scale bar, 100 µm (b–g)