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. 2018 Jul 3;9(7):745. doi: 10.1038/s41419-018-0761-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Representative score plots of the Principal Component Analysis (PCA) from metabolomics and lipidomics analyses. Score plots of the metabolomics MS data acquired in the negative mode on the LC-MSn°2 platform (A), the LC-MSn°1 platform in the positive mode (B), the GC-MSn°1 platform (C), and the NMRn°1 platform (D). Experimental conditions: control (open squares), docetaxel (plain triangles), lovastatin (open circles), and lovastatin + docetaxel (plain circles). Cells were treated for 36 h. The two dimensions of the analysis and their contribution to the variance are indicated. The data are representative of results from all platforms