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. 2018 Jul 3;9(7):745. doi: 10.1038/s41419-018-0761-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Central carbon metabolism in cancer. Metabolite and gene expression changes in response to (lovastatin + docetaxel) treatment for 36 h. The metabolomics and lipidomics signaling pathways were overlaid with the alterations in gene expression following (lovastatin + docetaxel) treatment compared to control cells after 36 h. The color code was as follows: blue boxes and blue circles referred to down-regulated genes and down-regulated metabolites, respectively. Red boxes and red circles referred to up-regulated genes and up-regulated metabolites, respectively