Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jul 3;8:10017. doi: 10.1038/s41598-018-28398-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Quantitative analysis of granule cell loss in the cerebellum of postnatally X-irradiated adult rats. (a) Granule cell area is significantly reduced in the cerebellum of X-irradiated rats compared to the cerebellum of non-irradiated control rats (C). In the P8⁶⁰⁰ irradiated cerebella, granule cell loss is significantly less than in the cerebella irradiated at the critical days P5-P6 in Groups P5²⁰⁰, P5⁶⁰⁰, P5⁸⁰⁰ and P6⁶⁰⁰. Bars show mean ± S.D. in all graphs. (b) Granule cell density is significantly decreased in the cerebellum of all X-irradiated groups compared to the cerebellum of non-irradiated control rats (C). A significant further decrease in granule cell density is also obtained with doses above 200 rads at P5 (P5⁶⁰⁰, P5⁸⁰⁰) and P6 (P6⁶⁰⁰). A dose of 600 rads produces significantly greater granule cell loss when delivered at P5 (P5⁶⁰⁰) or P6 (P6⁶⁰⁰) than at P7 (P7⁶⁰⁰) or P8 (P8⁶⁰⁰). (c) In the cerebellum of rats irradiated with 600 rads, granule cell loss is significantly greater in the late-developing lobules VI-VIII than in the early-developing lobules IX-X after irradiation at P5 (P5⁶⁰⁰) or P6 (P6⁶⁰⁰) but not at P7 (P7⁶⁰⁰) or P8 (P8⁶⁰⁰). The values of mean index of CF innervation m are indicated within the bars. *P ≤ 0.01.