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. 2018 Jul 3;8:9999. doi: 10.1038/s41598-018-28325-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Anti-α-Gal antibody levels in cases (malaria) vs controls (no malaria). (A) Infants and children from both sites together. (B) Stratified by age group. (C) Stratified by site. Data correspond to samples collected at M3 (after the third vaccine dose and prior the 12 months of follow up) from children participants in the RTS,S phase 3 clinical trial. Cases were defined as children with at least one episode of clinical malaria during the 12 months of follow up. Boxplots represent the median and interquartile range. Groups were compared through t-tests and p-values were adjusted for multiple comparisons through Benjamini-Hochberg and Holm (in parenthesis). Infant: 1.5–3 months; Children: 5–17 months.