Skip to main content
. 2018 Jul 3;8:10010. doi: 10.1038/s41598-018-28263-7

Table 4.

Investigation of ring B.

graphic file with name 41598_2018_28263_Figx_HTML.gif
Ring B hSUCNR1 mSUCNR1 ClogPb
pEC50 (efficacy, %)a
3c graphic file with name 41598_2018_28263_Figy_HTML.gif 5.75 ± 0.08 (72.8 ± 2.6) 6.46 ± 0.06 (79.3 ± 1.6) 1.66
25 graphic file with name 41598_2018_28263_Figz_HTML.gif 5.91 ± 0.11 (49.7 ± 3.9) 5.40 ± 0.13 (58.0 ± 4.5) 2.27
26 graphic file with name 41598_2018_28263_Figaa_HTML.gif 4% @10−4M 7% @10−4M 2.27
27 graphic file with name 41598_2018_28263_Figab_HTML.gif 6.03 ± 0.25 (78.2 ± 8.0) 6.10 ± 0.17 (89.3 ± 6.1) 2.05

apEC50 values were determined from dose-response curves of induction of IP3 turnover in SUCNR1 transfected HEK cells (N = 3), efficacy is determined relative to succinate (100%). bCalculated by BioByte’s algorithm as implemented in ChemDraw Professional 16.0.1.4 (ClogP option). cDuplication of data from Table 1.