Figure 3.

Nerve-tumor distance and nerve diameter are associated with survival. A-B: Representation of nerves not classified as PNI by the current definition, but with tumor cells in proximity to the nerve. C-E: Kaplan–Meier survival plots for Overall Survival. C: Patients stratified by the minimum distance between nerve and tumor considering all measured nerves for each patient and using a 5 μm cut-off. D: PNI negative patients split into two groups based on the same nerve-tumor distance cut-off as in C. E: PNI negative patients split into two groups based on the maximum nerve diameter per patient, using a cut-off of 80 μm. The number of patients at risk for each group at each time point is shown below the plots. Single arrows point the tumor cells, asterisks indicate nerves and double arrow indicates distance. Scale bars = 100 μm (A) and 500 μm (B).