Table 1.

Frequency of genetic variants of NOTCH1 mutations across different chronic lymphocytic leukemia studies.

No. patients	Mutation	Domain	%
646	P2514fs*4	PEST	78.78
35	c.*7668+371 A>G	UTR	4.2
14	Q2444*	PEST	1.7
10	L2482fs*1	PEST	1.2
10	c.*7668+378 A>G	UTR	1.2
6	Q2503*	PEST	0.73
5	Q2394*	PEST	0.61
4	Q2440*	PEST	0.48
4	Q2501*	PEST	0.48
3	S2336fs*12	TAD	0.36
3	S2341fs*14	TAD	0.36
3	Q2404*	PEST	0.36
3	A2463fs*14	PEST	0.36
3	F2481fs*2	PEST	0.36
3	Q2519*	PEST	0.36
2	Q2403*	PEST	0.24
2	Q2406*	PEST	0.24
2	Q2409*	PEST	0.24
2	P2415fs*82	PEST	0.24
2	Q2416HT	PEST	0.24
2	Q2416*	PEST	0.24
2	V2421*	PEST	0.24
2	Q2459*	PEST	0.24
2	S2470fs*1	PEST	0.24
2	V2476*	PEST	0.24
2	A2478fs*6	PEST	0.24
2	c.*7668+380 A>C	UTR	0.24
1	R2070W	ANK	0.12
1	R2104H	ANK	0.12
1	L2124fs*113	ANK	0.12
1	S2163del121	TAD	0.12
1	K2181fs*61	TAD	0.12
1	P2199fs*44	TAD	0.12
1	V2200fs*45	TAD	0.12
1	D2201fs*41	TAD	0.12
1	E2267fs*86	TAD	0.12
1	S2274fs*79	TAD	0.12
1	S2329fs*24	TAD	0.12
1	V2330fs*22	TAD	0.12
1	L2335fs*12	TAD	0.12
1	Q2391*	PEST	0.12
1	Q2395*	PEST	0.12
1	Q2398*	PEST	0.12
1	R2431 fs*4	PEST	0.12
1	F2433fs*2	PEST	0.12
1	L2434fs*1	PEST	0.12
1	L2434*	PEST	0.12
1	P2438fs*36	PEST	0.12
1	P2438fs*42	PEST	0.12
1	S2449fs*28	PEST	0.12
1	L2457V	PEST	0.12
1	E2460*	PEST	0.12
1	P2462fs*15	PEST	0.12
1	P2465fs*13	PEST	0.12
1	S2467*	PEST	0.12
1	S2467Y	PEST	0.12
1	S2467fs*6	PEST	0.12
1	L2468fs*4	PEST	0.12
1	T2477fs*6	PEST	0.12
1	Q2480fs*3	PEST	0.12
1	S2486*	PEST	0.12
1	Q2487*	PEST	0.12
1	S2492*	PEST	0.12
1	L2502V	PEST	0.12
1	Q2503fs*6	PEST	0.12
1	E2506*	PEST	0.12
1	L2510 del9 res	PEST	0.12
1	T2511A	PEST	0.12
1	E2515*	PEST	0.12
1	W2520*	PEST	0.12
1	D2531fs*74	PEST	0.12