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. 2018 Jul 3;9(7):751. doi: 10.1038/s41419-018-0771-y

Fig. 2. u50535 enhances CRC cell proliferation, inhibits apoptosis and accelerates cell cycle.

Fig. 2

a CCK8 assays revealed that u50535 silence inhibited HCT116 cell proliferation, while u50535 overexpression promoted DLD1 cell proliferation. b Apoptosis assays by flow cytometry indicated that u50535 silence increased apoptosis rate in HCT116, while u50535 overexpression decreased apoptosis rate in DLD1. c, d Cells in G0/G1 phase were mainly non-proliferation cells. u50535 silence increased the percentage of HCT116 cells in G0/G1 phase, while the overexpression of u50535 inhibited the percentage of DLD1 cells in G0/G1 phase. Data from three independent experiments were expressed as mean ± SD. * P < 0.05; ** P < 0.01