Table 5.

Sensitivity Analysis for Overall Survival; Cox Regression Analysis

	POSIBA				PULSE
	Multivariate S1		Multivariate S2		Multivariate S1		Multivariate S2
	HR (95% CI)	P Value	HR (95% CI)	P Value	HR (95% CI)	P Value	HR (95% CI)	P Value
DP	1.60 (0.96-2.67)	.072	1.72 (1.01-2.94)	.048	0.36 (0.19-0.69)	.0019	0.36 (0.19-0.69)	.0019
ECOG-PS >0	2.31 (1.56-3.43)	<.0001	2.49 (1.65-3.76)	<.0001	2.16 (1.10-4.25)	.026	2.16 (1.10-4.25)	.026
Age >65 years
BRAF mutated	2.40 (1.38-4.17)	.0019	2.57 (1.47-4.49)	.0010	3.52 (1.32-9.35)	.012	3.52 (1.32-9.35)	.012
Surgery of primary tumor	1.29 (0.88-1.90)	.19			0.33 (0.17-0.64)	.0013	0.33 (0.17-0.64)	.0013
Left-sided primary tumor
CEA (logarithmic term)	0.50 (0.33-0.75)	.0008	0.50 (0.32-0.76)	.0014
LDH (logarithmic term)
Liver metastasis
0
<=3, <=5 cm
>3 or >5 cm

CEA, carcinoembryonic antigen; CI, confidence interval; DP, double positivity; ECOG-PS, Eastern Cooperative Oncology Group performance status; HR, hazard ratio; LDH, lactate dehydrogenase; WT, wild-type.

S1: multivariate model including only the variables with a P value <.1 in the univariate analysis.

S2: multivariate model adjusted via automated stepwise selection of variables (see text for details).