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. 2018 May 28;20(7):710–720. doi: 10.1016/j.neo.2018.05.001

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© 2018 Published by Elsevier Inc. on behalf of Neoplasia Press, Inc.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Characterization of the blood-brain barrier integrity of the orthotopic murine glioma models. T2- and T1-weighted MRI of orthotopic (A) GSC457 and (B) p53^−/−;p16^Ink4a/p19^Arf−/−;K-ras^v12;Luc tumors. Some contrast enhancement was observed in both tumor models on T1-weighted images after gadolinium (Gd) administration. (C) GSC457 and (D) p53^−/−;p16^Ink4a/p19^Arf−/−;K-ras^v12;Luc glioma-bearing WT mice received TexasRed shortly prior to being sacrificed. Comparison of the hematoxylin and eosin (H&E) staining with fluorescence microscopy of coronal brain sections revealed heterogeneous TexasRed (TxRed) extravasation in the tumor regions (dashed circumscribed area) of both models, with some regions showing moderate extravasation (red arrows) and others showing little to no extravasation (white arrows).