Table 1.
Cohort | Foundation Medicine (FM) | Stand Up to Cancer (SU2C) | Checkmate-057 (CM-057) |
MDACC (PD-L1≥1%) |
||
---|---|---|---|---|---|---|
N | MDACC | MSKCC | DFCI/MGH | |||
924 (346 KRASMUT) | 174 | 44 | 66 | |||
62 | 56 | 56 | ||||
Nivolumab | NA | 146 | 24 | 16 | ||
Pembrolizumab | NA | 19 | NA | 40 | ||
Atezolizumab | NA | 0 | NA | 5 | ||
a-PD(L)-1/a-CTLA-4 | NA | 9 | NA | 3 | ||
Docetaxel | NA | NA | 20 | NA | ||
Other | NA | NA | NA | 2* |
One patient with STK11/LKB1 mutant tumor was treated with Nivolumab and NKTR-214 (CD122-based agonist) and one patient with STK11/LKB1 wild-type tumor was treated with pembrolizumab and OX40 agonist.