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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: J Neurochem. 2018 Apr 22;145(6):436–448. doi: 10.1111/jnc.14331

Fig. 3.

Fig. 3

CNO increased the spike firing in 50% of the recorded MSNs in D2 Gs-DREADD positive mice. (a) Representative example of spike train recorded in the striatum containing MSNs in a DREADD positive mouse. (b,c) autocorrelogram and ISI histogram (1 ms bin width) characterizing a MSN recorded in DREADD positive mouse. (d) Spike firing rate histogram of a MSN recorded in DREADD positive mouse showing an increase in the firing rate after 2.5 mg/kg CNO injection. Firing rates were calculated and plotted as the average frequency of discharge in 10-s bins. (e) Raster plots showing the spikes in a representative 60 s before and after CNO injection of an isolated MSN. Pooled data are shown in Fig. 2b,c.