Fig. 10. Intracellular Ca2+ Stores are Decreased in TSP-1−/− Compared to WT Lacrimal Gland Acini.
The size of intracellular Ca2+ stores was measured with a 15 min thapsigargin stimulation (10−5 M) in the absence of extracellular Ca2+. The peak [Ca2+]i (a), the total area under the curve (b) were measured over the 15 min period, and the rate of refilling was measured with the addition of extracellular Ca2+ (c) and compared between 24 week-old WT and TSP-1−/− mice. Data are mean ± SEM from three independent animals. * indicates a significant difference from WT. At least three independent experiments were performed.