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. Author manuscript; available in PMC: 2018 Dec 25.
Published in final edited form as: Nat Genet. 2018 Jun 25;50(7):1041–1047. doi: 10.1038/s41588-018-0148-2

Figure 1. S-LDSC and GCTA estimate for TopcisQTL are upward biased in simulations.

Figure 1

Panels (a), (b), (c), and (d) illustrate the true enrichment and S-LDSC and GCTA enrichment estimates for AllcisQTL, 95%CredibleSet, TopcisQTL, and MaxCPP annotations, respectively. GCTA is not applicable to continuous annotations (MaxCPP). The Y-axis indicates the mean of enrichment and error bars represent 95% confidence intervals that are computed for 400 simulations. Numerical results are reported in Supplementary Table 2. See Supplementary Table 3 and Supplementary Table 4 for additional simulation scenarios.