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. Author manuscript; available in PMC: 2018 Aug 19.
Published in final edited form as: Mucosal Immunol. 2018 Feb 19;11(4):1158–1167. doi: 10.1038/s41385-018-0009-4

Figure 6.

Figure 6

Viral dissemination to the spleen is predominately mediated by B cells and to a lesser extent by CD8 T cells. C57BL/6N (WT), RAG-/-, muMT-/-, CD8-/-, MHC-II-/-, and CCR2-/- male and female mice were infected i.rec. with LCMV. (a-c) Copies of LCMV per μg RNA were determined by qRT-PCR for specified tissues at day 5 p.i. or at days 1 to 3 p.i. (d). Data are pooled from three independent experiments. n = 8-12 per group (a-c), or 6-10 per group (d). Error bars represent mean ± SEM. Significance was determined with the Kruskal-Wallis test; *P < 0.05, **P < 0.01, ***P < 0.001. UI, uninfected.