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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Mol Cancer Ther. 2018 Apr 13;17(7):1526–1539. doi: 10.1158/1535-7163.MCT-17-0464

Figure 2. A Subset of Validated Resistance ORFs Reactivate MEK/ERK and/or PI3K Signaling.

Figure 2

A) Protein lysates from NCI-H2077 cells after treatment with DMSO or BGJ398 1 μM probed at different time points for key members of the canonical FGFR signaling pathway.

B) ORF-expressing NCI-H2077 cells after treatment with DMSO or BGJ398 1 μM for 1 hr and 24 hr were probed for FRS2, ERK and AKT activity (BGJ, BGJ398).