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Cytotoxic activity of the domain II mutant immunotoxins
| Construct | IC50 (pM) | Fold reduction in activity (compared to PE38) |
|---|---|---|
| LMB-2 (αTac-scFv-PE38) | 0.1 | |
| αTac-dsFv-PE38 | 0.1 | |
| αTac-dsFv-PE24 | 3.5 | 34 |
| αTac-dsFv-M12-PE24 | 30.2 | 297 |
| αTac-dsFv-M14-PE24 | 5.4 | 53 |
| αTac-dsFv-M15-PE24 | 1.5 | 15 |
| αTac-dsFv-M16-PE24 | 4.2 | 42 |
| αTac-dsFv-M17-PE24 | 3.2 | 32 |
| αTac-dsFv-M18-PE24 | 0.7 | 7 |
Immunotoxins were tested for cytotoxicity in a cell growth inhibition assay on the HUT-102 strain. Averages of 3-6 assays are shown.
