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. 2018 Jul 3;9(4):e00905-18. doi: 10.1128/mBio.00905-18

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Copyright © 2018 Perrin et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 3 — ΔGAP45 parasites show defects in expression of the glideosome components MyoA and MTIP. (A) IFA showing the subcellular localization of GAP45-HA3, MTIP, MyoA, and GAP50 in segmented schizonts of ΔGAP45 (RAP) and mock-treated (DMSO) GAP45:loxP parasites. Loss of GAP45-HA3 also resulted in loss of detection of MTIP and MyoA at the IMC upon RAP treatment. Bars, 5 µm. (B) Western blots showing the decreased overall abundance of MTIP and MyoA proteins in the absence of GAP45. (C) TEM images showing similar merozoite and IMC morphologies in GAP45-HA3 and ΔGAP45 parasites. Merozoite plasma membrane (PM), merozoite IMC, and schizont PVM are indicated. Bar, 0.5 µm.