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. 2018 Jul 3;9(4):e01034-18. doi: 10.1128/mBio.01034-18

TABLE 1 .

FDA-approved compounds that inhibit NDH-2 activity and S. agalactiae growth in vitroa

Compound IC50 (µM) GI50 (µM) Common use
Alexidine 16.79 ± 1.26 2.70 ± 0.51 Antiseptic
Caspofungin 15.23 ± 2.33 41.03 ± 2.62 Antifungal
Closantel 5.34 ± 0.65 0.25 ± 0.04 Antihelmintic (veterinary)
Triclabendazole 0.14 ± 0.02 15.30 ± 1.92 Antihelmintic
Zafirlukast 0.83 ± 0.07 6.07 ± 0.10 Asthma treatment
a

Cells were grown under respiration permissive conditions.