. 2018 Jun 27;474(2214):20180106. doi: 10.1098/rspa.2018.0106

Table 1.

Conserved moieties associated with chemostat selection. Across some biochemical subgroups (moiety), there are constraints (conserved quantity) on a corresponding sum of species representing the total of the moiety. The conserved quantities remain constant over the course of a simulation. Q represents contributions of other species to charge imbalance across the membrane. The symbol Σ represents charge contributions from Markov states of channels and transporters. The definition of Σ, and all species can be found in the electronic supplementary material and code.

	moiety	conserved quantity
conserved moieties common to all variants (A,B,C)
1	K1 channel	C_K1 + O_K1
2	K channel	S_00,K + S_10,K + S_20,K + S_01,K + S_11,K + S_21,K
3	Kp channel	C_Kp + O_Kp
4	Na channel	S_000,Na + S_100,Na + S_200,Na + S_300,Na + S_010,Na + S_110,Na + S_210,Na + S_310,Na + S_001,Na + S_101,Na + S_201,Na + S_301,Na + S_011,Na + S_111,Na + S_211,Na + S_311,Na
5	LCC	S_000,LCC + S_010,LCC + S_020,LCC + S_100,LCC + S_110,LCC + S_120,LCC + S_001,LCC + S_011,LCC + S_021,LCC + S_101,LCC + S_111,LCC + S_121,LCC
6	Na⁺/K⁺ ATPase	P1_NaK + P2_NaK + P3_NaK + P4_NaK + P5_NaK + P6_NaK + P7_NaK + P8_NaK + P9_NaK + P10_NaK + P11_NaK + P12_NaK + P13_NaK + P14_NaK + P15_NaK
7	NCX	P1_NCX + P2_NCX + P3_NCX + P4_NCX + P5_NCX + P6_NCX
8	troponin	TRPN + TRPNCa
9	calmodulin	CMDN + CMDNCa
dynamic ion concentrations (A)
	chemostats	MgADP, MgATP, Pi, H⁺
10	K⁺ ion	K⁺_i + K⁺_e + 2P1_NaK + P2_NaK + P12_NaK + 2P13_NaK + 2P14_NaK +2P15_NaK
11	Na⁺ ion	Na⁺_i + Na⁺_e + P4_NaK + 2P5_NaK + 3P6_NaK + 3P7_NaK + 3P8_NaK + 2P9_NaK + P10_NaK + 3P1_NCX + 3P6_NCX
12	Ca²⁺ ion	Ca²⁺_i + Ca²⁺_e + 2S_001,LCC + 2S_011,LCC + 2S_021,LCC + 2S_101,LCC + 2S_111,LCC + 2S_121,LCC + P3_NCX + P4_NCX + TRPNCa + CMDNCa
13	charge	Q − K⁺_i − Na⁺_i − 2Ca²⁺_i + 2TRPN + 2CMDN + Σ
dynamic intracellular ion concentrations (B)
	chemostats	MgADP, MgATP, Pi, H⁺, K⁺_e, Na⁺_e, Ca²⁺_e
10	charge	Q − K⁺_i − Na⁺_i − 2Ca²⁺_i + 2TRPN + 2CMDN + Σ
constant ion concentrations (C)
	chemostats	MgADP, MgATP, Pi, H⁺, K⁺_i, K⁺_e, Na⁺_i, Na⁺_e, Ca²⁺_i, Ca²⁺_e