Table 3.

Genes Commonly Found on Multigene Cancer Panels That Are Also Associated With Other Phenotypes in Individuals With Two Mutations.

Gene(s)	Heterozygous	Homozygous or Compound Heterozygous
ATM	ATM-associated hereditary cancer	Ataxia telangiectasia
BRCA2	Hereditary breast and ovarian cancer syndrome	Fanconi anemia (complementation group D1—FANCd1)
BRIP1	BRIP1-associated hereditary cancer	Fanconi anemia (complementation group J—FANCJ)
MMR genes	Lynch syndrome	Constitutional mismatch repair deficiency
NBN	NBN-associated hereditary breast cancer	Nijmegen breakage syndrome
PALB2	PALB2-associated hereditary cancer	Fanconi anemia (complementation group N—FANCN)
RAD51C	RAD51C-associated hereditary cancer	Fanconi anemia (complementation group O—FANCO)
RAD51D	RAD51D-associated hereditary cancer	Fanconi anemiaa

Note. Counseling for these syndromes should include discussion about reproductive risks. MMR = mismatch repair.

^a RAD51D is involved in the Fanconi anemia pathway, but there are no reported cases of Fanconi anemia with mutations in RAD51D.