Table 2.
Details of Participants With Rectal Screening Swab Samples Positive for Extended-Spectrum β-Lactamase Klebsiella pneumoniae
| Patient | Age, y | Sex | Recent Surgerya | Recent Antibioticsb | Isolatec | Antimicrobials to Which Resistance Was Detectedd |
|---|---|---|---|---|---|---|
| CH0031 | 96 | M | No | Cro | KSB1_1B | Kz, Cro |
| CH0138 | 91 | F | Yes | Tmp | KSB1_9D | Amc, Tim, Tzp, Kz, Caz, Cro, Gen, Tob, Cip, Nor, Tmp, Sxt |
| CH0142 | 72 | M | No | … | KSB1_4E | Tim, Tzp, Kz, Fox, Caz, Cro, Tob, Cip, Tmp, Sxt |
| CH0260 | 72 | F | No | Amc | KSB1_10J | Kz, Cro, Tmp, Sxt |
| CH0274 | 73 | F | No | Van, Cip, Cfx | KSB2_1B | Kz, Cro, Tmp, Sxt |
Abbreviations: Amc, amoxicillin–clavulanic acid; Caz, ceftazidime; Cfx, cefuroxime; Cip, ciprofloxacin; Cro, ceftriaxone; F, female; Fox, cefoxitin; Gen, gentamicin; Kz, cefazolin; M, male; Nor, norfloxacin; Sxt, trimethoprim-sulfamethoxazole; Tim, ticarcillin–clavulanic acid; Tmp, trimethoprim; Tob, tobramycin; Tzp, tazobactam-piperacillin; Van, vancomycin.
a“Recent surgery” indicates surgery of any kind in the last 30 days before screening.
b“Recent antibiotics” were defined as antibiotic treatment in the last 7 days before screening.
cCH0031 isolate KSB1_1B carried blaCTX-M-55; the others carried blaCTX-M-15.
dAntimicrobial resistance phenotyping was conducted using Vitek2 software and interpreted using Clinical and Laboratory Standards Institute thresholds. All isolates were confirmed resistant to ampicillin. Additional drugs to which acquired resistance was detected are listed. All 5 isolates were susceptible to cefepime, meropenem, and amikacin.