Table 2.
The patients' demographic and clinical information, fMRI command-following protocol results and functional connectivity results.
| Patient ID | Age range | Diagnosis | Interval since ictus, months | Score on CRS-R | Etiology | Command following (attention) | Movie DMN-DAN Connectivity | Resting DMN-DAN Connectivity |
|---|---|---|---|---|---|---|---|---|
| 1 | Visit 1: 22–25 |
VS | 67 | 6 | TBI | + | 0.21 | 0.32 |
| Visit 2: 26–30 |
VS | 89 | 7 | − | 0.38 | 0.32 | ||
| 2 | 31–35 | MCS | 445 | 9 | HBI | + | 0.44 | 0.48 |
| 3 | 18–21 | VS | 68 | 6 | HBI | − | 0.43 | 0.31 |
| 4 | 26–30 | MCS | 36 | 13 | HBI | + | 0.35 | 0.37 |
| 5 | 46–50 | MCS | 234 | 8 | HBI | + | 0.19 | 0.24 |
| 6 | 56–60 | VS | 38 | 6 | HBI | − | 0.37 | 0.13 |
| 7 | 31–35 | VS | 25 | 5 | HBI | − | 0.47 | 0.35 |
| 8 | 18–21 | VS | 3 | 6 | HBI | + | 0.29 | 0.46 |
| 9 | 41–45 | VS | 248 | 3 | TBI | + | 0.33 | 0.45 |
| 10 | 22–25 | MCS | 69 | 9 | TBI | + | 0.62 | 0.64 |
| 11 | 46–50 | MCS | 148 | 15 | TBI | − | 0.60 | 0.54 |
| 12 | 51–55 | VS | 11 | 4 | HBI | − | 0.63 | 0.64 |
| 13 | 51–55 | VS | 79 | 5 | HBI | − | 0.60 | 0.52 |
| 14 | 18–21 | VS | 49 | 5 | HBI | − | 0.66 | 0.25 |
| 15 | 36–40 | MCS | 38 | 7 | TBI | + | 0.13 | 0.38 |
VS, vegetative state; MCS, minimally conscious state; TBI, traumatic brain injury; HBI, hypoxic-ischemic brain injury; CRS-R, Coma Recovery Scale—Revised (57). In the “Command Following (Attention)” column, “+” denotes that the patient demonstrated a positive result, or showed evidence of command-following in the scanner; “–”denotes that the patient showed no evidence of command-following during this task. The Movie connectivity and Resting connectivity columns describe functional connectivity (as described by z-values) between the DMN and DAN.