Table 2.
Biochemical parameters of mineral metabolism | 129Sv |
B6 |
||||
---|---|---|---|---|---|---|
10 weeks |
10 weeks |
20 weeks |
||||
WT | Col4a3KO | WT | Col4a3KO | WT | Col4a3KO | |
PTH (pg/mL) | 281.5 ± 35.8 | 2521.6 ± 675.3a | 640.8 ± 215.8 | 770.2 ± 152.9 | 415.5 ± 62.2 | 3644.4 ± 1201.8a |
1,25(OH)2D (pg/mL) | 76.1 ± 14.4 | 43.0 ± 7.4 | 164.7 ± 18.1c | 170.4 ± 24.7c | 197.2 ± 23.5c | 203.1 ± 16.7c |
Pi (mg/dL) | 6.8 ± 0.3 | 14.1 ± 1.4b | 7.0 ± 0.5 | 7.5 ± 0.8 | 6.2 ± 0.4 | 8.9 ± 0.8a |
Ca2+ (mg/dL) | 10.4 ± 0.2 | 12.7 ± 1.3a | 10.5 ± 0.8 | 12.1 ± 0.5 | 7.6 ± 0.2 | 9.9 ± 0.5a |
FePi (%) | 6.5 ± 1.7 | 15.4 ± 2.7a | 9.5 ± 2.3 | 17.3 ± 2.5a | 4.8 ± 0.7 | 12.7 ± 1.9a |
FeCa (%) | 0.9 ± 0.4 | 10.6 ± 4.6a | 0.9 ± 0.3 | 1.2 ± 0.1 | 0.6 ± 0.1 | 3.6 ± 1.3a |
Values are mean ± standard error, n = 5 per group.
P < 0.05 versus aWT, ball groups and call 129Sv.