Table 2.
Frequencies of various forms of complex abnormality (>2 chromosomes with abnormal copy number) in day-3 (d3) blastomere biopsies and day-5 (d5) trophectoderm biopsies
| Type of complex abnormality | No. of d3 samples (%) | No. of d5 samples (%) |
|---|---|---|
| Diploid tripolara | 1149 (4.7%) | 81 (0.5%) |
| Digynic triploid tripolar | 94 (0.4%) | 14 (0.1%) |
| Diandric triploid tripolar | 27 (0.1%) | 0 (0.0%) |
| Digynic triploid/near-triploidb | 740 (3.0%) | 321 (1.9%) |
| Diandric triploid/near-triploidb | 25 (0.1%) | 32 (0.2%) |
| Maternal haploid/near-haploidb | 288 (1.2%) | 84 (0.5%) |
| Paternal haploid/near-haploidb | 126 (0.5%) | 25 (0.1%) |
| Multiple maternal chromosome gains (non-triploid) | 480 (1.9%) | 248 (1.5%) |
| Multiple paternal chromosome gains (non-triploid) | 61 (0.2%) | 40 (0.2%) |
| Both maternal and paternal gains (non-triploid) | 390 (1.6%) | 298 (1.7%) |
| Multiple maternal chromosome losses (non-haploid) | 360 (1.5%) | 93 (0.5%) |
| Multiple paternal chromosome losses (non-haploid) | 186 (0.8%) | 24 (0.1%) |
| Both maternal and paternal losses (non-haploid) | 448 (1.8%) | 44 (0.3%) |
| Otherc | 3576 | 1037 |
| Total | 7950 (32.2%) | 2341 (13.7%) |
a
Defined by possession ≥1 biparental disomy, ≥1 paternal monosomy, ≥1 maternal monosomy, and ≥1 nullisomy.
b
Near-triploidy and near-haploidy are defined by ≥20 trisomic and monosomic chromosomes, respectively.
c
Unclassified combinations of maternal and paternal chromosome gains and losses, as well as uniparental disomy.