Table 1. Comparison of the main features of MetaboAnalyst (versions 1.0 - 4.0) with other web-based or web-enabled tools. Symbols used for feature evaluations with ‘√’ for present, ‘-’ for absent, and ‘+’ for a more quantitative assessment, with more ‘+’ indicating better support.
| Tool name | MetaboAnalyst | XCMS online | Galaxy-M | W4M | Metabox | |||
|---|---|---|---|---|---|---|---|---|
| 4.0 | 3.0 | 2.0 | 1.0 | |||||
| Data processing | ||||||||
| Raw spectra | ++ | + | + | + | +++ | +++ | +++ | - |
| Data filtering | √ | √ | √ | - | √ | √ | - | - |
| Missing-value | √ | √ | √ | √ | - | √ | - | - |
| Normalization | +++ | +++ | ++ | ++ | - | ++ | ++ | ++ |
| Statistical analysis | ||||||||
| Univariate | +++ | +++ | +++ | ++ | + | ++ | ++ | ++ |
| Multivariate | +++ | ++ | ++ | ++ | ++ | + | +++ | + |
| Clustering | +++ | +++ | ++ | ++ | + | - | + | + |
| Classification | ++ | ++ | ++ | ++ | - | - | - | - |
| Power analysis | √ | √ | - | - | - | - | - | √ |
| Biomarker analysis | √ | √ | - | - | - | - | - | - |
| Functional analysis | ||||||||
| Enrichment | +++ | ++ | ++ | - | - | - | - | + |
| Pathway analysis | +++ | ++ | ++ | - | √ | - | - | √ |
| Mummichog | ++ | - | - | - | + | - | - | - |
| Data integration and systems biology | ||||||||
| Joint pathway analysis | √ | √ | - | - | √ | - | - | - |
| Knowledge -based network analysis | √ | - | - | - | - | - | - | √ |
| Correlation-based network analysis | - | - | - | - | - | - | - | √ |
| Biomarker meta-analysis | ++ | - | - | - | + | - | - | - |
• XCMS Online: https://xcmsonline.scripps.edu.
• Galaxy-M: https://github.com/Viant-Metabolomics/Galaxy-M.
• Workflow4Metabolomics (W4M): http://workflow4metabolomics.org/.
• Metabox: http://kwanjeeraw.github.io/metabox/.