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. 2018 Apr 24;27(14):2443–2453. doi: 10.1093/hmg/ddy145

Figure 5.

Figure 5.

Optic nerve ultrastructure and conduction are not affected in adult Fig4 iKO60d mice. (A, B) Representative TEM optic nerve cross section micrographs of adult Fig4 control and iKO(60→120) mice. Scale bar = 1 μm, n = 4 mice per genotype. (C, D) Representative optic nerve CAP traces recorded from adult Fig4 control and iKO(60→120) mice show three characteristic peaks. (E) Quantification of conduction velocities and (F) amplitudes for each peak within CAP traces identified by Gaussian fit. Data are shown as mean ± SEM. Multiple unpaired Student t-tests, n = 5 nerves (Fig4 control), n = 6 nerves (iKO).