Figure 5.
IL-17A and GDF15 induce epithelial-mesenchymal transition in HSAEpiC cells. (A) Representative images of cell morphology following exposure to IL-17A and/or GDF15 for 3 days (magnification, ×200). Cells were exposed to IL-17A and/or GDF15 for 3 days and the expression of E-cadherin, N-cadherin and vimentin was measured using (B) reverse transcription-quantitative polymerase chain reaction and (C) western blotting. *P<0.05 vs. control; #P<0.05 vs. GDF15 alone. IL, interleukin; GDF, growth/differentiation factor; E-cadherin, epithelial cadherin; N-cadherin, neural cadherin.