Table 1.

Major differences between daptomycin and daptomycin RF

Characteristic	Daptomycin for injection for IV use	Daptomycin RF for injection for IV use
Vial storage	• Refrigerated (2°C–8°C [36°F–46°F])	• Controlled room temperature (20°C–25°C [68°F–77°F]; excursions permitted to 15°C–30°C [59°F–86°F])
Diluent for vial reconstitution	• 0.9% sodium chloride	• Sterile water or bacteriostatic water for injection
Compatible IV solutions	• Daptomycin is compatible with 0.9% sodium chloride injection and lactated Ringer’s injection	• Reconstituted daptomycin RF is compatible with sterile water for injection, bacteriostatic water for injection, and 0.9% sodium chloride injection
Reconstitution of vial in preparation for administration	• To minimize foaming, AVOID vigorous agitation or shaking of the vial during or after reconstitution • Ensure that all the daptomycin powder is wetted by gently rotating the vial • Allow the wetted product to stand undisturbed for 10 minutes before gently rotating or swirling the vial contents for a few minutes to reconstitute	• Upon wetting the daptomycin RF powder with the diluent, the vial contents can be rotated and swirled immediately for a few minutes to reconstitute
Approximate osmolalitya of 50 mg/mL	• 364 mOsm/kg when reconstituted in 0.9% sodium chloride injection	• 323 mOsm/kg when reconstituted in water for injection
In-use storage period (once reconstituted)
Vial	Sodium chloride for injection	Sterile water for injection	Bacteriostatic water for injection
Room temperatureb	• 12 hours	• 1 day	• 2 days
Refrigeratedc	• 48 hours	• 3 days	• 3 daysd
IV bag preparation	Reconstitution: 0.9% sodium chloride for injection for immediate dilution with 0.9% sodium chloride injection	Reconstitution: sterile water for injection for immediate dilution with 0.9% sodium chloride injection	Reconstitution: bacteriostatic water for injection for immediate dilution with 0.9% sodium chloride injection
Room temperatureb	• 12 hours	• 19 hours	• 2 days
Refrigeratedc	• 48 hours	• 3 days	• 5 days
Syringe	No in-use storage period specified in prescribing information	Sterile water for injection	Bacteriostatic water for injection
Room temperatureb	• N/A	• 1 day	• 2 days
Refrigeratedc	• N/A	• 3 days	• 5 days

Notes: Data from package inserts of Cubicin® (daptomycin for injection)4 and Cubicin® RF (daptomycin for injection).7

^aOsmolality refers to the number of solute particles per kilogram of water; osmolarity refers to the number of solute particles per liter of water. Osmolarity is considered roughly equivalent to osmolality (ie, 1 L is approximately equal to 1 kg) because normal saline is a dilute aqueous solution with a specific gravity of 1.0003.

^bRoom temperature = 20°C–25°C (68°F–77°F).

^cRefrigerated temperature = 2°C–8°C (36°F–46°F).

^dStorage period is determined by sterility rather than stability of reconstituted product. Daptomycin RF is a new formulation of daptomycin for injection.

Abbreviations: IV, intravenous; N/A, not applicable.