Fig. 3.

Visualization and analysis of predicted PPI essentiality. (A) The network shows protein–protein pairs subjected for the MEDICI calculations to predict their essentiality for lung cancer cells. A total of 7906 PPIs are available for the analysis. The proteins are connected by lines colored based on the essentiality vales: E = 0—grey, 0 < E ≤ 0.2—black, 0.2 < E ≤ 0.4 – blue, 0.4 < E ≤ 0.6 – green, 0.6 < E ≤ 0.8 – orange, 0.8 < E ≤ 1 – red. (B) A subnetwork of PPIs included in the OncoPPi network and predicted as critical for lung cancer cell viability. A number of well-known oncogenic PPIs, e.g. RAF1-AKT, MDM2-TP53 or PIK3CA-PIK3R1 dimerization are predicted as essential for the cancer cells along with a set of novel PPIs, such as MYC-MAP2K3 or RASSF1-AKT1 (Color version of this figure is available at Bioinformatics online.)