Figure 4.

Model of the KRAS^G12D neoantigen-specific TCR, 3995. The full 3995 TCR model (containing TCR variable domains) is shown in (A), with α chain colored green, β chain cyan and CDR3 loops in dotted box. (B) Template alignments of model (‘Input’) CDR3α and CDR3β loops from the TCRmodel results page are shown, along with close-up view of modeled CDR3 loops, with loop apex residues shown as sticks. Selected CDR3α loop residues are labeled. Figure structures generated in PyMOL (Schrödinger, LLC).