Table 1.
SPM Results Showing Clusters, Peak Coordinates, and Significant Levels of Brain Regions with an Increase in 18F-FDG Uptake When Comparing THN102 to MOD, FLE, or VEH
| Intergroup Comparisons | Significant Clusters | Significant Peak Coordinates within Clusters | Peak Regions | ||
|---|---|---|---|---|---|
| x | y | z | |||
| THN102 > VEH | Cortex Caudate and putamen (Striatum) Amygdala |
0.5 | 4.6 | 3.6 | R pre-limbic cortex |
| 6.7 | 4.6 | -5.6 | R primary auditory cortex | ||
| -5.7 | 3 | -8.8 | L temporal association cortex | ||
| -0.1 | 1.2 | -0.2 | L cingulate cortex area 1 | ||
| -5.5 | 8.2 | -0.6 | L layer 3 of cortex | ||
| THN102 > FLE | Cortex Caudate and putamen (Striatum) Amygdala |
6.5 | 4.6 | -5.8 | R primary auditory cortex |
| 4.3 | 2.8 | 2.0 | R primary somatosensory | ||
| -5.5 | 8.6 | -4.8 | L layer 3 of cortex | ||
| -2.1 | 3.6 | 3.8 | L forceps minor corpus callosum | ||
| -3.1 | 0.4 | -7.8 | L primary visual cortex monocular | ||
| THN102 > MOD | Cortex Caudate and putamen (Striatum) Amygdala |
5.7 | 7.2 | -1.6 | R dysgranular cortex |
| 2.1 | 1.4 | 4.4 | R secondary motor cortex | ||
| 2.5 | 0.8 | -5.2 | R secondary visual cortex | ||
| -0.7 | 0.4 | -4.2 | L retrosplenialdysgranular cortex | ||
| -3.7 | 6.8 | 3.0 | L layer 3 of cortex | ||
| -5.5 | 8.6 | -4.8 | L basolateral amygdaloïd nucleus, posterior | ||
Voxels comparison-based analysis was performed using SPM8 (n=5) rats per group using 1-way ANOVA followed by multiple comparison test. A significance level threshold of .05 and a minimum cluster size of 200 voxels were selected to identify significant clusters. Coordinates of significant peak (P<.05) were given according to the Paxinos and Watson rat brain atlas (Paxinos and Watson, 2007). FLE, flecainide 1 mg/kg; MOD, modafinil 10 mg/kg; THN102, modafinil 10 mg/kg+flecainide 1 mg/kg; VEH, vehicle.