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. 2017 Sep 7;33(7):1268–1277. doi: 10.1093/ndt/gfx240

Table 1.

Summary of study key significant findings and sample size information

Study/date Sample and age (years) Design Comparative group, n (age ± SD) Time tested post-transplant Outcomes: domains assessed
Kramer et al. [14], Austria 15 transplant patients (45 ± 13) previously on HD Prospective longitudinal Within-subjects pre-transplant dialysis patients assessed after transplantation compared with healthy controls; 14 ± 5-month follow-up

  • Same sample assessed after transplant HD: 15 (45 ± 13)

  • Healthy controls: 45 (45 ± 13)

 14 months

  • General cognitive status

  • Information and motor speed
Harciarek et al. [46], Poland 27 transplant patients (46.1 ± 10.9) previously on HD: 17, PD: 10 Prospective longitudinal Within-subjects pre-transplant dialysis patients assessed after transplantation compared with dialysis and healthy controls; 8-month and 20-month follow-up

  • Subsample of transplant patients assessed after transplantation compared with those still on dialysis: Still dialysing: 18 (44.9 ±11.8)

  • HD: 12

  • PD: 6

  • Healthy controls: 30 (47.23 ± 10.2)

 None stated

  • Attention

  • Executive function

  • General cognitive status

  • Information and motor speed

  • Language

  • Spatial reasoning

  • Verbal fluency

  • Verbal memory

  • Visual memory
Griva et al. [26], United Kingdom 28 transplant patients (follow-up age not stated) previously on HD: 10, PD: 18 Prospective longitudinal Within-subjects pre-transplant dialysis patients assessed after transplantation; 6-month follow up

  • Same sample assessed after transplant dialysis: 28 (44.04 ± 12.01)

  • HD: 10

  • PD: 18

  • Standardized norms

 6 months Executive function Information and motor speed Verbal memory Visual memory
Radic et al. [24], Croatia 21 transplant patients (45.14 ± 7.86) previously on HD Prospective longitudinal Within-subjects pre-transplant dialysis patients assessed after transplantation; 20 ± 8-month follow-up

  • Same sample assessed after transplant

  • HD: 21 (45.14 ± 7.86)

 20.5 months

  • Executive function

  • Spatial reasoning

  • Verbal memory
Griva et al. [25], United Kingdom 117 transplant patients (50.26 ± 12.33) Cross-sectional transplant patients compared with dialysis patients

  • Dialysis: 145 (50.12 ± 14.26)

  • HD: 77

  • PD: 68

 None stated

  • Executive function

  • Information and motor speed

  • Verbal memory
Troen et al. [11], Israel 183 transplant patients (54 ± 9.5) Cross-sectional transplant patients assessed only compared with norms Standardized norms None stated

  • Executive function

  • Information and motor speed

  • Spatial reasoning

  • Verbal memory
Gelb et al. [48], Canada 42 transplant patients (55.24 ± 10.96) Cross-sectional transplant patients compared with healthy controls and CKD patients CKD patients: 45 (59.67 ± 11.88) Healthy controls: 49 (57.00 ± 13.59) None stated

  • Executive function

  • Verbal memory
Martinez-Sanchis et al. [30], Spain 32 transplant patients (42.69 ± 8.28) Cross-sectional transplant patients compared with healthy controls Healthy controls: 10 (37.20 ± 9.90) None stated

  • Attention

  • Executive function

  • Information and motor speed

  • Verbal fluency

  • Verbal memory

  • Visual memory
Anwar et al. [47], Egypt 50 transplant patients Cross-sectional transplant patients compared with dialysis and healthy controls

  • Dialysis: 50 (45 ± 9.5)

  • Healthy controls: 30 (45 ± 9.5)

 None stated

  • Executive function

  • General cognitive status

  • Information and motor speed
Ozcan et al. [49], Turkey 69 transplant patients (50.9 ± 16.5) Cross-sectional transplant patients compared with dialysis patients

  • Dialysis: 112 (51.21 ± 13.45)

  • HD: 54 (51.1 ± 12.5)

  • PD: 58 (51.33 ± 14.4)

 None stated General cognitive status

Age ± SD refers to mean age ± standard deviation.